Emergency Services are currently at the scene of a crash at Welby.
Just before 11am, a B double travelling south, crossed onto the northbound lanes and then ran off the Hume Motorway.
A salvage operation is currently underway and one of two northbound lanes are currently closed.
The driver was taken to Bowral Hospital with leg and arm pain.
Police, the Rural Fire Service and Paramedics are in attendance.
Motorists are being asked to allow extra travel time.