Emergency Services are currently at the seen of a two vehicle crash at Alymerton near Mittagong.
The crash involving two vehicles took place just after 2:30pm on the Old Hume Highway.
NSW Paramedics say a 40 year old female is trapped, but conscious and breathing.
A rescue helicopter has been called in and motorists travelling in the area are being asked to exercise caution.
IMAGE CREDIT: NSW Ambulance