The Crash Investigation Unit has been called into investigate a fatal crash which took place at Wilton.
Just before 6am on Saturday, Emergency services were called to Picton Road, near Macarthur Drive.
Police have been told a vehicle towing a boat and a utility collided.
The male driver of the utility died at the scene.
His male passenger and the male driver and sole occupant of the second vehicle were both treated by paramedics before being rushed to Liverpool Hospital in a serious condition.
Two other vehicles were also hit and sustained minor damage.
IMAGE CREDIT: NSW Paramedics