Emergency Services were called about 7.20am to Culburra Road at Wollumboola following reports a 4WD and truck had collided.
Police said the male driver of the 4WD died at the scene.
He is yet to be formally identified.
The truck driver, a man believed to be aged in his 20s, sustained injuries to his arm and has been taken to hospital for treatment and mandatory testing.
Officers from South Coast Police District have commenced investigations to determine the circumstances surrounding the collision.
Image: David Nightingale