The Princes Highway south of Nowra is closed in both directions in Jerrawangala due to a serious car and truck crash.
The highway is closed between Armchair Road and Twelve Mile Road.
Motorists are advised to delay their trip or avoid the area as there is currently no suitable diversion.
Motorists already in the area should follow the directions of emergency services and traffic crews on site and allow plenty of extra travel time.
For the latest traffic information, visit www.livetraffic.com or download the Live Traffic NSW app.